Studies toward the Total Synthesis of Itralamide B and Biological Evaluation of Its Structural Analogs
نویسندگان
چکیده
Itralamides A and B were isolated from the lipophilic extract of Lyngbya majuscula collected from the eastern Caribbean. Itralamide B (1) showed cytotoxic activity towards human embryonic kidney cells (HEK293, IC50 = 6 μM). Preliminary studies disapproved the proposed stereochemistry of itralamide. In this paper, we will provide a full account of the total synthesis of four stereoisomers of itralamide B and the results derived from biological tests of these structural congeners.
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عنوان ژورنال:
دوره 13 شماره
صفحات -
تاریخ انتشار 2015